Alleviating
Metabolic Syndrome

Alleviating
Metabolic Syndrome

Metabolic syndrome is a cluster of conditions such as high blood pressure, high blood sugar, unhealthy cholesterol levels, excess abdominal fat which can increase your risk of heart disease, stroke and type 2 diabetes.

If you have metabolic syndrome, aggressive lifestyle changes can delay or even prevent the development of serious health problems.

Symptoms

The two major obvious symptoms associated with metabolic syndrome are a large abdominal waist, increased thirst and urination, fatigue and blurred vision when the blood sugar is high.

Why Caviarlieri

Chronic inflammation may represent a triggering factor in metabolic syndrome: If you are genetically or metabolically predisposed, obesity, physical inactivity and ageing would result in cytokine hypersecretion, which will eventually lead to insulin resistance and diabetes.

Caviarlieri is a Swiss Caviar Food Supplement formulated with the finest Caviar Cellular Extracts, marine peptides and highly polymerized collagen, which have strong anti-inflammatory properties that can help to alleviate metabolic syndrome and the symptoms associated with this condition.

Caviarlieri is scientifically proven to help reduce Tumour Necrosis Factor Alpha, which is an important inflammatory biomarker for metabolic syndrome conditions. In addition, Caviarlieri can also reduce the C-reactive protein (CRP), a blood test marker for inflammation in the body. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.

There are also several current and ongoing studies which indicate that Caviarlieri triggers the epigenetic mechanisms of the cells to activate gene expression for inflammation reduction, which will help to alleviate the onset of any of the risks associated with metabolic syndrome.

Strong Anti-Inflammatory Properties of Caviarlieri help Alleviate Metabolic Syndrome

A sturgeon-derived bioactive compound beneficially modulates nuclear receptors controlling metabolic functions in patients with metabolic syndrome

Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 84-53-60/2013

A. Lorenzetti, R. Catanzaro, G. Bertuccelli, N. Zerbinati, . Jain, U. Solimene, S.K. Yaduvanshi, N. Srivastava, E.Minelli, H. Yadav, C. Tomella, F.Marotta

The aim of the study was to test the possible effects of a novel sturgeon-derived compound Caviar DNA Extract (LD-1227) in Caviarlieri on inflammatory markers related to metabolic nuclear receptors in patients with metabolic syndrome. The study population consisted of 76 patients with metabolic syndrome and 30 healthy subjects who were maintained to their current treatments and randomly supplemented with A) Caviar DNA Extract (LD-1227) (n=38) or B) placebo (n=38) as compared to C) healthy controls (n=30). Caviar DNA Extract (LD-1227) or placebo (water-soluble starch) were given daily at breakfast and dinner for three months.

At the end of the study period, as compared to B group, Caviar DNA Extract LD-1227-treated patients showed a significant improvement of all parameters (hs-CRP, IL-6, TNF-alpha) tested, irrespective of the presence of diabetes. Although the metabolic syndrome remains a multifaceted condition requiring a complex approach, Caviarlieri (LD-1227) could be a potential safe therapeutic tool to be integrated into a wider treatment and preventive medicine schedule strategy.

Throughout the whole study, the level of IL-6 was significantly higher in Metabolic Syndrome patients as compared to healthy controls and it was not affected by the presence of diabetes (p<0.05, fig 1). After intervention with Caviar DNA Extract (LD-122), IL-6 level decreased significantly in all Metabolic Syndrome patients (p <0.05 vs baseline and vs placebo group).

Note: Interleukin-6 is a cytokine not only involved in inflammation and infection responses but also in the regulation of metabolic, regenerative, and neural processes.

After intervention with Caviar DNA Extract (LD-1227), TNF-α level (inflammation) decreased significantly in all Metabolic Syndrome patients (p<0.05 vs baseline and vs placebo group).

The level of hs-CRP in patients with Metabolic Syndrome was significantly higher than in healthy controls (p<0.05, fig 2) and particularly in those with overt diabetes (p<0.05 vs MS patients without diabetes). After intervention with Caviar DNA Extract (LD-1227), hs-CRP significantly decreased (p<0.05 vs placebo).

Note: C-reactive protein (CRP) is a blood test marker for inflammation in the body. CRP is produced in the liver and its level is measured by testing the blood. CRP is classified as an acute phase reactant, which means that its levels will rise in response to inflammation.

A high-sensitivity C-reactive protein (hs-CRP) test, which is more sensitive than a standard test, also can be used to evaluate your risk of developing coronary artery disease, a condition in which the arteries of your heart are narrowed. Coronary artery disease can lead to a heart attack.

Conclusive Summary

Metabolic Syndrome represents a cluster of metabolic abnormalities including abdominal obesity, hypertension, hyperlipidaemia, and diabetes. This condition confers an increased risk for vascular disease-associated morbidity and mortality, even in the absence of clinically evident cardiovascular disease (CVD) and/or diabetes mellitus (DM).

It is evident from the above studies that Caviarlieri is a potent and effective supplement for alleviating metabolic syndrome by reducing inflammation. After administering Caviar DNA Extract (LD-1227), levels of all tested cytokines (inflammatory biomarkers) in Metabolic Syndrome patients markedly decreased whereas their levels remained unchanged in patients receiving placebo. This suggests that Caviar DNA Extract (LD-1227) in Caviarlieri could provide protection for Metabolic Syndrome patients and that this protection was proportionally more evident even for patients with diabetes.

More remarkably, the intervention with Caviar DNA Extract (LD-1227) has shown in human chondrocytes that this sturgeon-derived compound could effectively inhibit IL-1β-induced proliferation and inflammatory reactions via inhibited activation of the transcription factor NF-κB pathway. Caviarlieri contains collagen elastin, protein and a rich array of other smaller unsaturated fatty acids, and structural phospholipids which may exert a synergistic action on multiple mechanisms of the inflammatory cascade.

Caviarlieri can therefore effectively help in the regulation of key metabolic nuclear receptors functions and diminish the inimical onset and risk of metabolic syndrome.

Other Evidence-Based Benefits of Caviarlieri

Significant Reduction in Inflammation

Caviarlieri is scientifically proven to have very strong anti-inflammatory properties. Formulated with the finest Caviar Cellular Extracts, marine peptides and highly polymerized collagen, it can help reduce chronic inflammation.

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Significant Increase in Cellular Energy

Caviarlieri Swiss Caviar Cellular Therapy Supplement provides effective and essential nutrition at the cellular level, accelerating protein synthesis, stimulating cellular repair and renewal against damaged cells, providing you more energy, endurance and stamina.

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Strengthens Immunity

Caviarlieri is formulated with potent bioactive ingredients like Sturgeon Caviar DNA cellular extract and high quality marine peptides which are known to enhance B cell activity and could be useful for those with a compromised immune system.