Substantial Reduction
in Joint Pain

Substantial Reduction
in Joint Pain

Musculoskeletal pain, particularly joint and back pain, is the most common type of chronic pain. The most common cause of joint pain is related to arthritis, of which there are numerous types. Patients routinely seek medical attention for joint pain, and it is one of the leading causes of disability.

Joint problems and diseases worldwide today ranks fifth amongst all forms of disability, affecting 10 percent of the world’s population over the age of 60. It is also estimated that degenerative joint disorders will affect 130 million individuals worldwide by the year 2050.

It is inevitable that the majority of people suffering from joint pain are dependent on painkillers and drugs like NASIDs (nonsteroidal anti-inflammatory drugs). This is a very serious problem as many of those drugs and painkillers have adverse side effects. Long-term use of certain NSAIDs can lead to side effects including stomach problems, kidney problems, high blood pressure, fluid retention, and other allergic reactions.

Opioids (also known as narcotics) are also prescribed to treat moderate to severe pain. However with long-term use, they too have other side effects such as hormonal dysfunction including reduced fertility and libido, immunosuppression, testosterone depletion, and abnormal pain sensitivity.

NASIDs and Opioids also become less effective after some time.

Why Caviarlieri

Caviarlieri is a Swiss Caviar Food Supplement formulated with the finest Caviar Cellular Extracts and marine peptides and highly polymerized collagen which have strong anti-inflammatory properties. It can help to alleviate and reduce chronic joint pain significantly.

Unlike painkillers or opioids which have adverse side effects, Caviarlieri is an excellent nutritional supplement which has no side effects and is a palliative for chronic pain management. Scientific studies of Caviarlieri published in peer reviewed journals have demonstrated that its primary bio active ingredient, Caviar DNA Extract is more effective than DHA and its positive results become more significant over time (18 weeks).

Empirical randomised double-blind placebo studies of the key ingredients of Caviarlieri also show outstanding results for knee osteoarthritis and back pain. In a published scientific study on Caviarlieri, it was reported that Caviarlieri can also reduce the Tumour Necrosis Factor Alpha which is an important inflammatory biomarker for arthritis and fibromyalgia. There are also several ongoing studies which indicate that Caviarlieri triggers the epigenetic mechanisms of the cells to activate gene expression for inflammation reduction.

Effective Treatment for Osteoarthritis with
No Side Effects

Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage that cushions the ends of your bones wears down over time. It is a progressive chronic disease that can lead to impaired joint function and will result in excruciating pain and disability.

Published in Peer Reviewed Journal – Acta Bio Medical / Official Journal of the Society of Medicine and Natural Sciences of Parma Vol 84-N1/2013

Testing a novel bioactive marine nutraceutical (Caviarlieri) on Osteoarthritis patients

The primary objective of the study was to test the effectiveness of the Caviar bioactive compound versus a common nutraceutical intervention like GC (glucosamine/chondroitin sulphate) in knee osteoarthritis patients. The patient population involved in the study consisted of 60 subjects who had a recent diagnosis of knee osteoarthritis of mild-moderate severity. The patients were randomized in two groups in a double-blind study comparing Caviar Extract LD-1227 (group A) versus a mixture of glucosamine (500 mg), chondroitin sulphate (400 mg) (group B). Patients were allowed their established painkillers on demand. At 4, 9 and 18 weeks patients were evaluated based on various validated pain score systems like VAS score which assesses pain at rest, and during physical exercise, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale and KOOS scale.

Figure 1. Pain at Rest (VAS core) through week 18: Effect of Caviar DNA Extract versus GC Treatment

It is evident from the above figure 1 that after 4 weeks, patients treated with Caviar DNA extract (LD1227) showed a decline in VAS Score
( p < 0.05 ) which means that the pain (at rest) for these patients is significantly lower those treated with Glucosamine Chondroitin (GC).

Note: VAS Score is a 0-100mm Visual Analog Scale Score system which assesses pain during the most painful knee movement.

Figure 2. Pain During Physical Activity (VAS Score) through week 18: Effect of Caviar DNA Extract versus GC Treatment

This graph shows the assessment of pain during routine physical activity and it is obvious that both treatments yielded comparable improvement at the 4th week. However, from week 9th till week 18th, patients treated with Caviar DNA extract (LD-1227) showed a significantly lower pain intensity as compared to those on GC.

Figure 3. Koos Scale Evaluation – Reduction of Pain for Knee Osteoarthritis Subjects using Caviar DNA and GC Treatment

This graph shows that once again that Caviar DNA extract (LD-1227) can help reduction in pain and is a outstanding option for pain management in the long term.

Note: KOOS (Knee disability and Osteoarthritis) score system is divided into 5 segments namely pain symptoms, function in daily living, function in recreation, other symptoms and quality of life.

Figure 4. Koos Scale Evaluation – Function in Recreation for Knee Osteoarthritis Subjects using Caviar DNA and GC Treatment

Patients treated with Caviar DNA extract (LD-1227) have excellent sustainable improvements in recreational functionality from baseline to week 18 as compared to GC.

Figure 5. Womac Asessment of Patients with Knee Osteoarthrtis Treated with Caviar DNA Extract Versus GC – Level of Pain

This graph confirmed and reinforced the results and outcomes measured using VAS Score and KOOs score system in terms of significant pain reduction for Knee Osteoarthritis patients administered with Caviar DNA extract (LD-1227) as compared to GC.

Note: WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index)

Figure 6. Womac Assessment of Patients with Knee Osteoarthritis Treated with Caviar DNA Extract Versus GC – Stiffness

Graph demonstrates that patients administered with Caviar DNA extract (LD-1227) have reported significant reduction in the stiffness of their joints from baseline to 18th week compared to GC.

Biochemical Monitoring of Inflammatory Markers in Patients with Knee Osteoarthritis Treated with Caviar DNA (LD-1227) and GC

Biochemistry Analysis – Blood tests

Patients in the two groups were tested for inflammatory markers like Tumour Necrosis Factor Alpha, C Reactive Protein, Interleukin 6 etc, cytokines during the 18 weeks study period after taking the Caviar DNA extract (LD-1227) versus those taking GC.

Table 7 demonstrates that patients administered with Caviar DNA extract (LD-1227) have demonstrated significantly Lower Inflammation over time as compared to GC. This implies that Caviarlieri can not only help to reduce joint pain and chronic inflammation over time.

Conclusive Summary

Most doctors usually prescribe Glucosamine Chondroitin for osteoarthritis patients suffering from joint pain. However, it is evident from the above studies that Caviarlieri is far more potent and effective for the long-term reduction of joint pain as compared to the widely prescribed glucosamine chondroitin. In addition, Caviarlieri’s strong anti-inflammatory properties will also reduce disability, enhance recovery and functional physical mobility significantly.

Empirical Randomised Double Blind Placebo Clinical Studies on Key Ingredients of Caviarlieri on Osteoarthritis

Effect of Marine Peptides in Caviarlieri on Osteoarthritis after a month

This graph explains how patients who were administered with marine peptides in Caviarlieri after a month have all reported significant improvements in their physical performance. 21% of the patients also reported complete relief from pain.

Effect of Marine Peptides in Caviarlieri on Osteoarthritis after 24 days

This graph explains the reduction of pain between treatment with marine peptides in Caviarlieri versus Diclofenac. After 42 days, patients who were treated with Caviar & Marine Cellular DNA reported a 39% reduction in pain.

Cartilage Repair and Growth

Effectiveness of Marine Peptides in Caviarlieri in reducing intra-cellular collagenase (growing chondrocyte/cartilage cells) – anti-osteoarthritis basic effect

This graphs shows that by significantly inhibiting or reducing intra-cellular collagenase, Marine Peptides in Caviarlieri helps facilitate the growth of chondrocytes (cartilage cells), thereby demonstrating a strong anti-osteoarthritis effect.

Note: When chondrocytes cells break, it becomes easier for bacteria or inflammatory elements to enter our system. Therefore, is it essential that we grow chondrocytes and also inhibit the breaking down of extra cellular matrix – important for fighting or battling osteoarthritis.

Conclusion

It is evident from both the Caviarlieri scientific studies and empirical studies on the key ingredients of Caviarlieri, that there is consistency in terms of sustainable results and outcomes in significantly reducing joint pain, improving functional mobility and the quality of life for Osteoarthritis patients without adverse side effects over time.

Effective Treatment for Rheumatoid Arthritis

Rheumatoid Arthritis is an autoimmune condition that brings about inflammation in your joints which leads to pain, swelling and stiffness in joints. This condition causes the immune system to attack healthy body tissues. Rheumatoid Arthritis is commonly known to affect the knees, feet and hands and there is no cure. However, the damage and pain can be reduced or managed with early and continuous treatment.

The graph above shows that marine peptides in Caviarlieri have a beneficial effect on swollen joints.

Other Evidence-Based Benefits of Caviarlieri

Supports Bone Health

Marine peptides inherent in Caviarlieri have properties which are beneficial for bone health and support. The peptides help increase the organic component of bones including the bone microarchitecture. It helps to improve bone formation and bone density and also prevents bone loss.

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Significant Reduction in Inflammation

Caviarlieri is scientifically proven to have very strong anti-inflammatory properties. Formulated with the finest Caviar Cellular Extracts, marine peptides and highly polymerized collagen, it can help reduce chronic inflammation.

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Significant Increase in Cellular Energy

Caviarlieri Swiss Caviar Cellular Therapy Supplement provides effective and essential nutrition at the cellular level, accelerating protein synthesis, stimulating cellular repair and renewal against damaged cells, providing you more energy, endurance and stamina.