What is Fish Collagen?

Fish Collagen is collagen protein derived from fish, specifically fish skin, scales, and bones. Fish collagen is special because it comes from such an abundant marine source. It is a Type I collagen, which is a type of collagen found almost everywhere in our body.

Why is the Highly Polymerized Fish Collagen Elastin more Potent?

1. Fish Collagen Peptides – High Digestibility and Enhanced Absorption

The fish collagen in Caviarlieri is hydrolysed, which means it has undergone hydrolysis, a clean, enzymatic process that involves breaking the collagen down to more digestible collagen peptides for maximum bioavailability and effectiveness and therefore it is easily absorbed into our body.

There is a significant difference between fish collagen proteins and peptides. Both peptides and proteins are made up of our body’s basic building blocks, the amino acids which are tied up in bonds . The key difference is that the fish collagen peptides are made up of smaller chains of amino acids than proteins, which means it facilitates enhanced bioavailability and better absorption in our body. The average molecular mass of the HP Fish Collagen Elastin in Caviarlieri is 3.6 kDa, making it completely soluble.

1. High Polymerized – Low molecular mass

But a peptide doesn’t have as many amino acids as a protein does. The process of polymerization will potentially enhance the potency of the fish collagen ingredient. During polymerization, smaller molecules of the fish collagen peptides are chemically combined to create a macromolecule or polypeptide. When a chain 10 or more amino acids form as a single strand, it is known as a polypeptide. A polypeptide is formed by the polymerization of the amino acids. The fish collagen peptide embedded in Caviarlieri is highly polymerized thereby enhancing its potency and effectiveness.

1. High Polymerized – Low molecular mass

Marine or fish elastin peptides are known to promote the biosynthesis of new elastin fibres. This will boost the synthesis of collagen fibres and stimulate skin cell proliferation.

Created in the same ratio as our skin, the HP Collagen Elastin in Caviarlieri comprises the highest premium marine grade quality of hydrolysed collagen and elastin peptides for optimal benefits for our overall health and wellness.

CAVIARLIERI CLINICAL STUDIES

The Powerful Scientifically Proven HP Fish Collagen Peptides with Elastin

1. Skin and Complexion

A. Smoothing & Anti-Wrinkle Effect After 28 Days of Treatment

In the HP Collagen Elastin group, a significant decrease of the number of deep wrinkles was observed after 28 days for 71% of the subjects. The average deep wrinkles reduction was equal to 10% (see graph 1).

The Placebo group showed a deterioration of the cutaneous relief with a significant increase in the number of deep wrinkles of +28% for 82% of the subjects.

Graph 1: Variation of the number of deep wrinkles on Day 28 – HP Collagen Elastin plus versus Placebo groups

B. Protective Effect After 84 Days of Treatment

• No significant variation in the cutaneous relief parameters in the group after 84 days.
• In the placebo group, a significant increase in the number of deep wrinkles of +51% on D84 was observed in 88% of the subjects

These results highlight the protective effect of against the harsh winter conditions. Between day 28 and day 84, skins were exposed to cold temperatures, which explain a weaker anti-wrinkle effect at this period. Indeed, the study was conducted in the winter season and the skin had to fight against harsh conditions. The protective effect of is confirmed by the observation of the deep wrinkle number variation in the group versus Placebo (graph 2).

Conclusion

The results of the study confirmed previous published researches on collagen peptides. THE COMBINATION OF the two main constituents of the extracellular matrix, has a synergic anti-wrinkle action: elastin fibers will give the dermis the suppleness and then complete the collagen fibers tensile strength. When orally administered at 2g/day,and elastin peptides will stimulate the biosynthesis of the dermis main constituents to lift and tone slackened areas. minimizes apparent lines and wrinkles as shown in the results of the clinical studies.

2. Nutritional Efficiency for Joint Pain and Cartilage Protection

A. Osteoarthritis is a condition which is a result of repeated mechanical stress exertion on our cartilage causing the dissociation and the complete local destruction of the cartilage. This condition, which usually occurs in subjects aged over 60, is three times more common in women than in men.

Various clinical studies have concluded that collagen has the beneficial effect of reducing the sensation of pain in patients after 60 days of treatment and thus, reduces their consumption of painkillers.

One of the studies was published in the journal of Hindawi titled “Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial” (https://www.hindawi.com/journals/tswj/2012/342854/)

Another published study is titled “Marine Collagen Hydrolysates Downregulate the Synthesis of Pro-Catabolic and Pro-Inflammatory Markers of Osteoarthritis and Favour Collagen Production and Metabolic Activity in Equine Articular Chondrocyte Organoids” (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826754/).

B. Rheumatoid arthritis on the other hand is a chronic inflammatory rheumatic disease, characterized by the damaged synovial membrane. The membrane gradually gets thicker and causes progressive destruction to the cartilage and other structures within the joint (Figure 1). Rheumatoid arthritis is both a systemic and an auto-immune condition.

Trentham’s study, conducted in 1993, showed that hydrolysed collagen had a beneficial effect on swollen joints.

Figure 2: Number of Swollen Joints with and without Hydrolyzed Collagen

C. Fibromyalgia

Fibromyalgia is a condition that causes pain all over the body (also referred to as widespread pain), sleep problems, fatigue, and often emotional and mental distress. Till date, there is no treatment for Fibromyalgia.

Hydrolysed Collagen is known to have an analgesic effect and therefore it can potentially inhibit the transmission of pain. It also contributes in reducing the discharge of irritant factors and inflammation transmitters within the joint.

What is the Technology used in the Extraction Process used in the manufacturing of Caviarlieri

Using exclusively patented Swiss Proprietary Cold “Cellularix” DNA extraction technologies, Caviarlieri’s HP Collagen Elastin are kept biologically active during the entire manufacturing process. This ensures the potency and effectiveness of the micro nutrients and ensure optimal absorption and results at the cellular level.

Other European Food Safety Authority Approved ingredients in Caviarlieri

1. Caviar Cellular DNA and Marine Peptides

Sturgeon Caviar is an exceptional nutritional ingredient, rich in amino acids and essential fatty acids. Combined with marine fish peptides, the bioactive caviar DNA extract can be potentially beneficial in the following activities : cardioprotective, immunomodulatory, analgesic, anxiolytic anti-diabetic, appetite suppressing and neuroprotective.

1. Coenzyme Q10

Coenzyme Q10 is an antioxidant that your body produces naturally and it helps provide energy to cells. Our cells use CoQ10 for growth and maintenance.

Levels of CoQ10 in your body decrease as you age and CoQ10 levels have also been found to be lower in people with certain conditions, such as heart disease, and in those who take cholesterol-lowering drugs called statins.

1. Selenium

Selenium is a trace mineral which plays an important role in cell division and providing immune support.

It also helps the antioxidants work better. Antioxidants help protect our cells from oxidation reactions caused by molecules called free radicals. While people only need a very small amount, selenium plays a key role in the metabolism, and helps to protect our body from oxidative stress particularly in our heart and brain.

It is also known that selenium helps to activate and deactivate specific thyroid hormones, encouraging thyroid function & protecting the thyroid gland from oxidative stress.

Synergistic Formulation of Caviarlieri Explains its Potency

Caviarlieri, the Caviar Food Supplement is backed by extensive scientific research studies, which are published in world renowned peer reviewed journal and also in PubMed and Europe PMC. These studies validate the supreme rejuvenative, regenerative and anti-aging therapeutic benefits of the unique synergistic formulation of Caviarlieri.

An Exclusive and Effective Caviar Supplement with Reputable Accreditation

Caviarlieri is not a drug but an oral food supplement approved by the Swiss Public Health Authority. Unlike drugs or medications, there are no side effects for long term use. Caviarlieri is also certified by “Cologne List” as it is free of steroids, hormones and stimulants which makes it safe for long-term use.